Two sample MR report
HLA-A_Conventional Dendritic Cell against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 68 | -0.1067828 | 0.0996140 | 0.2876393 |
| Weighted median | 68 | -0.0410095 | 0.0085037 | 0.0000014 |
| Inverse variance weighted | 68 | -0.0411544 | 0.0075037 | 0.0000000 |
| Simple mode | 68 | -0.0868233 | 0.0324249 | 0.0093148 |
| Weighted mode | 68 | -0.0859538 | 0.0236179 | 0.0005327 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 187.6939 | 66 | 0 |
| Inverse variance weighted | 188.9354 | 67 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.035929 | 0.0543785 | 0.511091 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0016838 | 4e-07 | TRUE | 0.0001162 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
